Child with pain in hands and feet

  My 7 year old daughter had scarlet fever (group A strep on throat culture).
  She started Amoxicillin on a Sunday night..  Monday, Wed and Thurs mornings
  she has complained of sudden onset of tingling and pain on the palms of her
  hand, her thumbs, and the soles of her feet.  It starts about 5 minutes
  after awakening, is quite severe, and stops after about 5 minutes,
  subsiding over a couple of minutes.  
  It does not seem to be triggered by anything special,
  and does not seem to be a hysterical reaction to anything (this is very
  different from her usual '7 going on 17' tantrum).
       Could it be an odd effect from the amoxicillin, or a sequelae to the
  strep?  Is it anything I should worry about?
  Thank you,
Dear MMH:
Sorry to hear about your daughter's paraesthesias.  There isn't anything in the literature concerning neuropathy associated with numbness or tingling.  However, there are numerous reports about allergic reactions, mild swelling, rash and itching.  I would talk to your pediatrician about the reaction (actually, I am also a board certified pediatrician and have never seen this type of reaction).  There is nothing new under the sun and this may be a reaction particular to your daughter.  Has she ever had amoxicillin before (I guess that she would if like other children she probably had ear infections)?  Strep throat can also be treated with other medications and so I would just change medications.  But, you should find out from your pediatrician what she/he wants to do.  Best of luck.
Sincerely,
CCF Neuro[P] MD,RPS