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Thanks for writing in.
Diffuse cerebral atrophy and focal gliosis indicate brain damage. Some amount of cerebral atrophy occurs normally with increasing age. In your uncle’s case age and ischemic damage have contributed to cerebral atrophy.
Ischemic damage occurs due to blockade of small blood vessels in the brain which is common in hypertensives, diabetics, smokers and chronic alcoholics.
Hope this helps!