Does this mean anything

I have had many seemingly unrelated symptoms but together they really are starting to bother me. If any of the following touch a cord with anyone please let me know if there is something I can do about it.

I am a 35 year old female.

I am experiencing:

Hot flashes (feels like heating from the inside out)
Hair loss
Constant Fatigue
Severe and constant muscle fasciculation in my right calf (for over a year)
Charlie horses in the same calf frequently
Muscle weakness (rubbery feeling) in my thighs
A general lack of interest in anything

I thought I was depressed due to my fatigue and lack of interest, so I saw a psychiatrist and am now on Effexor. The depression has improved slightly, but I am still tired all of the time and have no interest in any of my old hobbies.