With the widespread
fasciculationsMuscle twitching you report, if this was ALS I would have expected signs of denervation on the EMG. But if the EMG was completely
normalNormal saline flush except for one lone fascic in your thumb and you have no other objective signs of weakness or reflex changes on your exam, then the possibility of ALS is very very unlikely. As you know, fascics are not specific for ALS and can be caused by bad discs in the neck or back, benign fasciculation syndrome or other disease that can irritate the motor neuron. The clinical exam and history are eseential in determining the correct diagnosis. If a bad disc or some kind of neck disease is suspected, pushing on the nerve roots to your arm, then the exam and possibly an MRI of the cervical spine may help in further evaluation. GOod luck.