Not necessarily, but I certainly can't predict what your body is going to do with the Avonex. Research studies have shown that Rebif (which is a higher dose preparation of beta interferon than Avonex) is more associated with elevated liver enzymes than Avonex. In a European-North American trial, 14 patients on Rebif had liver side effects compared to only 7 patients on Avonex. It's possible that it could be a dose response effect, meaning the side effects come out with the higher doses. Talk to your doctor about your concerns. Although they may have left the decision up to you, they should discuss the potential side effects of all the medications and help you make an informed decision that is best for you. Good luck.