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I had much smaller fibroids than what you mention, a complex cyst on the left too, and lived with the exact pain you describe (10 yrs) when various therapies offered no relief. Once I hit menopause, the pain stopped -- progesterone cream helped. I am now dealing with a whole other issue, but when I mentioned the return of this exact same leg pain following what neuro thinks might have been a form of stroke, my neuro said women often encounter left leg pain (and slight ankle swelling, etc) due to the position of the uterus affecting the nerves on that side. Depending on your age, you may want to discuss this condition with a OB/GYN -- some women find relief after hysterectomies, but balanced hormones make a huge difference too (ask about a blood panel to check testosterone, progesterone, thyroid, and estrogen levels) -- a better, less radical first approach in my opinion.