Neurology Expert Forum
Hallucinations
About This Forum:

This forum is for questions and support regarding neurology issues such as: Alzheimer's Disease, ALS, Autism, Brain Cancer, Cerebral Palsy, Chronic Pain, Epilepsy, Fibromyalgia, Headaches, MS, Neuralgia, Neuropathy, Parkinson's Disease, RSD, Sleep Disorders, Stroke, Traumatic Brain Injury.

Font Size:
A
A
A
Background:
Blank
Blank
Blank
Blank Blank

Hallucinations

My father-in-law has Parkinson's and is also on dialysis.  Recently, he was prescribed Amantadine 200 mg per day.  He began to have hallucinations.  His neurologist said this was due to the Parkinson's and it was just a coincidence that it started when he went on Amantadine.  He said the Amantadine is metabolized in the liver, so his being on dialysis has no bearing on the dosage.  Is this correct?  What should we do?
Related Discussions
Avatar_n_tn
Amantadine is actually excreted unmetabolized in the urine. Patients with kidney disease need to have the ok by their kidney doctors before starting on the medication as it can accumulate in the body with impaired kidney function, especially if they require dialysis. There is one study from the Annals of Medicine in 1980 that looked at dialysis patients and levels of amantadine before and after dialysis. THey found that only a small fraction of the drug was removed with each dialysis treatment.

And yes, it can cause hallucinations, especially when it's withdrawn too quickly or if there's too much in the body. On the other hand, dopamine and dopamine like drugs can also cause hallucinations. This can be treated with decreasing the med or adding an antipsychotic medication such as Seroquel or Olanzapine. In your father in law's case, talk to his renal doc to make sure that amantadine is ok. Then discuss your concerns with his neuro. Good luck.
1 Comment
Blank
Avatar_f_tn
A related discussion, weening off Amantadine was started.
Blank
Continue discussion Blank
Blank
Request an Appointment
MedHelp Health Answers
Blank
Weight Tracker
Weight Tracker
Start Tracking Now
RSS Expert Activity
242532_tn?1269553979
Blank
How to Silence Your Inner Critic an...
Apr 16 by Roger Gould, M.D.Blank
242532_tn?1269553979
Blank
Emotional Eaters: How to Silence Yo...
Mar 26 by Roger Gould, M.D.Blank
1344197_tn?1392822771
Blank
Vaginal vs. Laparoscopic Hysterecto...
Feb 19 by J. Kyle Mathews, MD, DVMBlank