Inmuran dosis

[Jeannette013]

Right now the Doctor increased my Inmuran dosis fron 150 to 200 daily and I am feeling a litle better.  Now my Doctor wants me to increase the Inmuran dosis to 300 daily for 1 1/2 week, down to 250 daily for another week and then go down to 200 daily.  I am concerned about the side effects of that high dosis.  Would like your comments.  Thanks

[bhups1]

Hi, “IMURAN is usually given on a daily basis. The initial dose should be approximately 1.0 mg/kg (50 to 100 mg) given as a single dose or on a twice-daily schedule. The dose may be increased, beginning at 6 to 8 weeks and thereafter by steps at 4-week intervals, if there are no serious toxicities and if initial response is unsatisfactory. Dose increments should be 0.5 mg/kg daily, up to a maximum dose of 2.5 mg/kg per day. Therapeutic response occurs after several weeks of treatment, usually 6 to 8; an adequate trial should be a minimum of 12 weeks. Patients not improved after 12 weeks can be considered refractory. IMURAN may be continued long-term in patients with clinical response, but patients should be monitored carefully, and gradual dosage reduction should be attempted to reduce risk of toxicities”. Taken from http://www.rxlist.com/cgi/generic/azathioprine_ids.htm

The principal and potentially serious toxic effects of IMURAN are hematologic and gastrointestinal. The risks of secondary infection and neoplasia are also significant. The frequency and severity of adverse reactions depend on the dose and duration of IMURAN as well as on the patient's underlying disease or concomitant therapies. The incidence of hematologic toxicities and neoplasia encountered in groups of renal homograft recipients is significantly higher than that in studies employing IMURAN for rheumatoid arthritis. Taken from http://www.rxlist.com/cgi/generic/azathioprine_ids.htm

[bhups1]

hi, what is the indication of this drug, i mean what for you are taking this drug?