Until July 1991 I was a healthy woman of 35. I then got as tick in my arm during camping and didn't get it out for five days. One week later followed with fever, chills, sore muscles, stiff neck etc. Rec'd Kenalog injections and Surgam. Didn't help much. Six months later friend returned from India with lung infection ?viral illness and stayed a few days with me. Twelve days later had stiff neck, severe headache,vomiting, fever, chills, sweats etc. This was in Feb. 1992. In mid-Feb began to have cognitive problems, felt like I had the "flu". Ended up in hospital for two weeks, no corneal reflex, optic neuritis, positive brain MRI, chorea, myoclonic jerks, dysarthria, painful legs. intial lesions included three-quarters of left temporal lobe, two areas of high signal in the right parieto-occipital region, right posterior centrum semioval, occiptal lobe of the lateral ventricle and others distantin the left hemispere. Consistant with inflammory disorder or ischemia Positive anti-cardiolipid antibodies, neg. spinal tape for oligoclonal banding, lympocytes and moncytes present and nucleated cells, depressed glucose, normal proteins. I was also very short of breath. Depressed C3, elevated CQ1 binding, elevated IGM, sed rate less than one, low anion gap, gross hematuria. Hypogammaglomunemia, with a selective IGA defiencey was picked up. Positive Shirmers.. All blood work to date neg. for Sjogren's,. Four spinal taps and eight years later still relapsing. Now they think this is MS? Brain continues to demylenate. I have no ankle or arm reflexes, neurogenic dysphagia, neurogenic pain both arms, severe headaches, tanal falls, glomular nephritis, . I have cerebritis or cerebral encepalatis twice in past two years, both times lastin g four months. Only treatment prednisone, until recently Plaquenil. Can you offer some insight I am getting worse and have no ansers, except maybe they think its MS. PS Past five weeks mucle twitching at rest waist down. Losts of sensory symptoms from onset. Tank you for your service. You have a great site. Tricia