Muscle fasiculation / twitching

  Hi,
     I have been getting twitching in my muscles for the past 2 yrs or so, it
  has not increased significantly in the past 2 yrs but has been quite constant
  I get twitching in my thighs, legs, arms, shoulders and on occasion around
  my eyes.  
      I have noticed muscle loss but that is over a period af about 5-6 yrs, but
  then again my muscles were larger when I was in college.  Over the past
  2 yrs I have been feeling physically stressed, I'm always "tight".  My right
  hamstring muscle is ALWAYS flexed (almost 80% of the day).  Tightness in shoulder,
  neck, chest quite often.
      My doctor says "relax" and do some exercise (I haven't worked out in
  about 4 yrs).  When I do exercise I feel extremely week (aerobic), muscles
  feel like they're going to give way (don't get much twitching then).  Most of
  the twitching is when I'm sitting around doing nothing.
     Can this all be STRESS?  I also get a lot shoulder/neck pain that could
  be related to CTS/RSI due to computer use as I'm a System Analyst and spend
  a good chunk of my day at a computer.  
     Done alot of blood work, cardio tests etc.  Everything supposedly normal.
  I have highblood pressure and am taking medication for it, so it is under control
  right now.  Other than the fasiculations I ALWAYS feel tight and nervous, most days, all day!
  Apparently, thyroid and renal glands are OK.
  Thanks,
  Kevin.
=======================================================================
Thanks for your question.  Although you did not mention it directly in your
message, it is clear from the "posting topic" that you chose that you have
concerns whether your symptoms are indicative of ALS.  A number of factors
make this possibility less likely, the main one being the duration of your
fasciculations (over 2 years).  The muscle mass loss that you have noticed
could be the consequence of a sedentary life, particularly if during the
previous years your were a very physically active person.  Similarly the
"tightness" that you have mentioned could result from a combination of
inadequate posture during the long hours at work, and the sedentary (and
possibly stressful) lifestyle.
Regarding the possibility of Carpal Tunnel Syndrome (CTS), the most common
symptoms are numbness and/or tingling in the tips of the first three digits
(thumb, index, and middle fingers) that can worsen at night time (even
waking you up from sleep).  Much less frequently, patients can complain
about dull forearm pain.  But discomfort in the shoulder/neck region is
definitely not related to CTS.  The cause of CTS is an entrapment/compression
of the median nerve around the wrist region, thus not affecting the nerves
closer to the shoulder region.
If the symptoms are causing you unusual discomfort I would suggest an
appointment with a neurologist specialized in neuromuscular diseases to
address both the fasciculations and the shoulder/neck pain.
I hope this information is helpful.  Best of luck.
This information is provided for general medical education purposes only.
Please consult your doctor regarding diagnostic and treatment options.