First of all, keep in mind that I am unable to diagnose you because I am unable to examine you, this forum is for educational purposes. The symptoms you describe are non-specific, but could be experienced by someone with multiple sclerosis (MS). The presentation of MS varies, but often presents with painful visual loss (optic neuritis) or isolated areas of numbness/tingling, each that resolve in 3-4 weeks. Fatigue is also a common symptom. The MRI findings that you describe may or maynot be significant. Non-specific white matter spots can be seen in a number of differnt processes such as migraine headaches, high blood pressure, MS and for unknown reasons. Lesions become more concerning for MS if they align with the corpus callosum and if they are perpendicular to the corpus callosum. More benign spots tend to be in the subcortical areas and in the centrum semi-ovale (area of white matter).
The concern of lyme disease is also significant. These type symptoms can be found in Lyme, but are not specific for it. Things that would increase your risk for having lyme would include, living in a lyme endemic area, history of a tick bite, circular rash, and joint pain. Your initial test for lyme was neagtive, which is reassuring, but they can sometimes be negative until the disease is treated.
With the symptoms you describe I would reccomend lumbar puncture (spinal tap) with the spinal fluid sent for Tourtelotte panel, oligoclonal bands, Kappa Free light chains and Lyme IgG and IgM (talk to your neurologist about these tests). I would also recommend visual evoked potentials, that will test for prior evidence of optic neuritis (given your history of a blind spot).
If concern is higher for lyme due to risk factors mentioned earlier, I would recommend a trial on antibiotics and a possible SPECT scan.
I know how frustrated you must feel going from being able to do everything to being limited in what you could do.
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Aliyah