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Numbess /Tingling can B12 deficiency
I like to share my story in this forum to see if anyone have similar symptoms and what their recommendations.
Starting from may 2005 i had numbness /tingling in left leg and both arms. My GP did normal test which include thyroid panel as well , everything came back normal my Tsh was 3.45 according to him it was normal . I started having tiredness/severe depression/muscless weakness & pain and Peripheral Neuropathy in extremities . I went to neurologist in August he did series of test which include thyroid as well ,he discover my Tsh was 13, he also performed EMG which came back normal.
From Sept i have been taking Levothyroxine started from 100mcg, my symptoms did improve but tingling /numbess increased in both hands/feet. My GP perform B12 level test , it came back 282 so she said start B12 supplement of 1000mcg a day and also gave me one injection of 1ml same day. However still i have same probem I went to second neurologist in Dec , he did another series of test which include some antibodies as i have Hashimotos so decided to other antibodies test to rule Mysthenia gravis , in those test he did MMA and Homecystine as well , in dec my B12 level was 600 but MMA level came back 345 /normal Homocystiene which shows my oral B12 is not doing job although it increase the B12 level but MMA is high enough to tell B12 defiency . My Neuro did not pay attention on that and started Neurointin 400mg a day , my GP thinks it is anxiety so she started Cymbalta , my throid doctor said your thyroid is normal TSH 1.24, FT4 1.68. So he is off the hook. ..
I don't know where to go by searching so many forums i found if MMA is high you have B12 deficiency , i finally changed my GP and new GP did series of test again and started put me on B12 injection daily . I so far have 2 injections . She is planning to have 1x7 , 1 xweek for 4 weeks and 1 in a month B12 injections.
I am waiting for MMA level result . In any of my test it shows i have aneamia .
Please share your stories and let me know if i am on right track .
Thanks
Starting from may 2005 i had numbness /tingling in left leg and both arms. My GP did normal test which include thyroid panel as well , everything came back normal my Tsh was 3.45 according to him it was normal . I started having tiredness/severe depression/muscless weakness & pain and Peripheral Neuropathy in extremities . I went to neurologist in August he did series of test which include thyroid as well ,he discover my Tsh was 13, he also performed EMG which came back normal.
From Sept i have been taking Levothyroxine started from 100mcg, my symptoms did improve but tingling /numbess increased in both hands/feet. My GP perform B12 level test , it came back 282 so she said start B12 supplement of 1000mcg a day and also gave me one injection of 1ml same day. However still i have same probem I went to second neurologist in Dec , he did another series of test which include some antibodies as i have Hashimotos so decided to other antibodies test to rule Mysthenia gravis , in those test he did MMA and Homecystine as well , in dec my B12 level was 600 but MMA level came back 345 /normal Homocystiene which shows my oral B12 is not doing job although it increase the B12 level but MMA is high enough to tell B12 defiency . My Neuro did not pay attention on that and started Neurointin 400mg a day , my GP thinks it is anxiety so she started Cymbalta , my throid doctor said your thyroid is normal TSH 1.24, FT4 1.68. So he is off the hook. ..
I don't know where to go by searching so many forums i found if MMA is high you have B12 deficiency , i finally changed my GP and new GP did series of test again and started put me on B12 injection daily . I so far have 2 injections . She is planning to have 1x7 , 1 xweek for 4 weeks and 1 in a month B12 injections.
I am waiting for MMA level result . In any of my test it shows i have aneamia .
Please share your stories and let me know if i am on right track .
Thanks
Do you think thyroid can manifest all those symptoms ? a big YES... you could blame any thing on this very important organ in our body
Do you answer this from experience? I had numbness in my feet, my hands are no longer numb, but I have numbness in my forehead and temple. I too, had high MMA, and I am taking b12 injections. How do you decipher if the numbness is coming from b12 deficiency or thyroid? I also have Hashimotos, and I have had problems regulating my thyroid for almost 3 years. Hopefully, this dosage I'm on will be it for me.
Do you answer this from experience? I had numbness in my feet, my hands are no longer numb, but I have numbness in my forehead and temple. I too, had high MMA, and I am taking b12 injections. How do you decipher if the numbness is coming from b12 deficiency or thyroid? I also have Hashimotos, and I have had problems regulating my thyroid for almost 3 years. Hopefully, this dosage I'm on will be it for me.
I'm so sorry I did not see your Qs..it would have been better if you posted a new qs...anyway
My question is if my MRI of brain is clear that means i should not have MS (Multiple Sclerosis), correct or should i look for some other things as well to rule out MS? NO, YOU DO NOT NEED ANY MORE TESTS .
In regards to ALS , is there any test i should do to rule out this ALS ? YOUR EMG WAS NORMAL
Bob
My question is if my MRI of brain is clear that means i should not have MS (Multiple Sclerosis), correct or should i look for some other things as well to rule out MS? NO, YOU DO NOT NEED ANY MORE TESTS .
In regards to ALS , is there any test i should do to rule out this ALS ? YOUR EMG WAS NORMAL
Bob
I am sure you must be busy with other prioirty issues. If you can spare some time please answer my last post in your conveience .
Your help is greatly appreciate it
Your help is greatly appreciate it
Once again i really thank you for your replies help in this forum very actively.
I just have one more question which may help me reduce my anxiety about my health.
My question is if my MRI of brain is clear that means i should not have MS (Multiple Sclerosis), correct or should i look for some other things as well to rule out MS .
In regards to ALS , is there any test i should do to rule out this ALS ?. or based on what i gave you explanation about my symptoms and test result, you think i just have either b12 or thyroid and some anxiety and nothing else .
Once again Bob what you are doing for people after retirement is really great work , God will give you great benefit for this cause and help. ..
I just have one more question which may help me reduce my anxiety about my health.
My question is if my MRI of brain is clear that means i should not have MS (Multiple Sclerosis), correct or should i look for some other things as well to rule out MS .
In regards to ALS , is there any test i should do to rule out this ALS ?. or based on what i gave you explanation about my symptoms and test result, you think i just have either b12 or thyroid and some anxiety and nothing else .
Once again Bob what you are doing for people after retirement is really great work , God will give you great benefit for this cause and help. ..
You are welcome,
injection for last 3 days it can be high but not sure would it cause any negative impact ?
the only reported effect ,though not proved, is stimulate sexual desires
I have also issues with muscless weakness in my arms +started having pain in my arm above elbow and wrist as well . ..try to give them some time before using any symptomatic therapy!! they will go away
symptoms take time to heal up even with normal thyroid level? Yes
Bob
injection for last 3 days it can be high but not sure would it cause any negative impact ?
the only reported effect ,though not proved, is stimulate sexual desires
I have also issues with muscless weakness in my arms +started having pain in my arm above elbow and wrist as well . ..try to give them some time before using any symptomatic therapy!! they will go away
symptoms take time to heal up even with normal thyroid level? Yes
Bob
Thanks a lot for your reply . My Potassium level in last 10 months test done in different time frame is always 4.3-4.7 , which sounds to be normal...
Is there any problem if your B12 level is higher than normal because i am taking B12 injection for last 3 days it can be high but not sure would it cause any negative impact ?.
I have also issues with muscless weakness in my arms specially which give me even hard time to hold cell phone longer when i am talking to some one , i started having pain in my arm above elbow and wrist as well .
If my thyroid level get normal , should my symptoms go away or those neurological symptoms take time to heal up even with normal thyroid level.
Once again i really thank you for your help.
Is there any problem if your B12 level is higher than normal because i am taking B12 injection for last 3 days it can be high but not sure would it cause any negative impact ?.
I have also issues with muscless weakness in my arms specially which give me even hard time to hold cell phone longer when i am talking to some one , i started having pain in my arm above elbow and wrist as well .
If my thyroid level get normal , should my symptoms go away or those neurological symptoms take time to heal up even with normal thyroid level.
Once again i really thank you for your help.
You are welcome,
Before I go to your Qs, I want to say that its not only the compression effect in hypothyroidism could cause your symptomes, its also well known that hypothyroidism cause a direct damage to the nerve axons (any nerve has a body and an axon, say like an arm extends from the spin to the hands and feet) which takes some time to recover
My question is do you think one b12 injection can rapidaly drop MMA level ? Yes but not immediately.....this question remind me of an imprtant issue with B12 injections which could cause a transient low potassium (causes exhusion, fatigue, worse tingling)...make sure your potassium level in the blood at least a 4 (different labs..3-5.2 is normal)
Do you recommend any test which i can do to rule other possibilities ?NO , except the Potassium level
Do you think thyroid can manifest all those symptoms ? a big YES... you could blame any thing on this very important organ in our body
Bob
Before I go to your Qs, I want to say that its not only the compression effect in hypothyroidism could cause your symptomes, its also well known that hypothyroidism cause a direct damage to the nerve axons (any nerve has a body and an axon, say like an arm extends from the spin to the hands and feet) which takes some time to recover
My question is do you think one b12 injection can rapidaly drop MMA level ? Yes but not immediately.....this question remind me of an imprtant issue with B12 injections which could cause a transient low potassium (causes exhusion, fatigue, worse tingling)...make sure your potassium level in the blood at least a 4 (different labs..3-5.2 is normal)
Do you recommend any test which i can do to rule other possibilities ?NO , except the Potassium level
Do you think thyroid can manifest all those symptoms ? a big YES... you could blame any thing on this very important organ in our body
Bob
In addition to my last post . My Neuro did perform Ab receptor and blocking for MG which came back negative, i also done MRI for Brain which came back normal which little bit of sinus on left side .
Do you think thyroid can manifest all those symptoms ?
Do you think thyroid can manifest all those symptoms ?
Thanks for your reply . I changed my GP as she was not listening to me in part of b12 injections according to her if B12 level increase with oral supplement i am not pernicious aneamia although my MMA level was high. The New GP performed series of test which include MMA level and TSH also before i performed those test 18 hours prior to those test she gave me one B12 injection and also keep in mind i continously taking B12 supplement of 1000mcg . The test result came out with all normal , even MMA is 0.16 /IF AB for blocking is negative , however my TSH went down way low , it is now .002 so i became Hyper due to enough dose of levoxyl/cytomel (0.75mcg/10mcg) .
My question is do you think one b12 injection can rapidaly drop MMA level ?.
All my symptoms are weakness in muscles/fatigue /joint pains/numbness and tingling only on feet and palm/wrist , which i am thinking could because of nerve compress due to thyroid which can give carpal tunnel and tarsal tunnel syndrome but don't know why muscles weakness and pain.
Do you recommend any test which i can do to rule other possibilities ?
Your help here is greatly appreciate it .
My question is do you think one b12 injection can rapidaly drop MMA level ?.
All my symptoms are weakness in muscles/fatigue /joint pains/numbness and tingling only on feet and palm/wrist , which i am thinking could because of nerve compress due to thyroid which can give carpal tunnel and tarsal tunnel syndrome but don't know why muscles weakness and pain.
Do you recommend any test which i can do to rule other possibilities ?
Your help here is greatly appreciate it .
Hi,
It was a very wise way of your doctors to look for M gravis, or even episodic hypokalemia as a possible cause of your symptomes in a case of hoshimotoe's " Common things are common" and its also wise to give b12 injection if your level is remain low ,
One thing would stop me if your MMA only continued to be high..though its more sensitive than homocystein level, but this sensitivity will be lost in case you continue to be symptomatic and B12+ Hom are normal...Meaning we have a different diagnosis called Methylmalonic acidemia, which a disease of infants esp if breast fed by a vegan/vegetrian mothers or children....but an adult or
It was a very wise way of your doctors to look for M gravis, or even episodic hypokalemia as a possible cause of your symptomes in a case of hoshimotoe's " Common things are common" and its also wise to give b12 injection if your level is remain low ,
One thing would stop me if your MMA only continued to be high..though its more sensitive than homocystein level, but this sensitivity will be lost in case you continue to be symptomatic and B12+ Hom are normal...Meaning we have a different diagnosis called Methylmalonic acidemia, which a disease of infants esp if breast fed by a vegan/vegetrian mothers or children....but an adult or
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