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Primary Lateral Sclerosis (PLS) & amyloidosis
My husband has been diagnosed with PLS (Primary Lateral Sclerosis) and amyloidosis.  Just this past week he has been treated with IgG to help slow the progress of these diseases.  Do you have any patients that are suffering from PLS & amyloidosis?  Are they taking any other type of treatments that help with these diseases.  Is their research that is being done regarding PLS and amyloidosis?  Any help is greatly appreciated.  Thank you.
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Hello sunshine2115
Treatment for individuals with PLS is symptomatic. Baclofen and tizanidine may reduce spasticity. Quinine or phenytoin may decrease cramps. Physical therapy often helps prevent joint immobility. Speech therapy may be useful for those with involvement of the facial muscles.
PLS is not fatal.  There is no cure, and the progression of symptoms varies.  Some people may retain the ability to walk without assistance, but others eventually require wheelchairs, canes, or other assistive devices
In amyloidosis treatment options depends on the type of amyloidosis and involves correcting organ failure .C ancer chemotherapy medication melphalan ,Alkeran,is being researched in conjunction with bone-marrow stem-cells transplantation. The results have been promising, and this combination treatment is offered to eradicate the amyloidosis in selected patients, provided that the underlying medical condition of the patient is adequate. These aggressive treatment options with stem-cell transplantation and high doses of chemotherapy are a true breakthrough in the treatment of these patients.
You should discuss regarding these options with your physician and hope for the best.

Reference http://www.ninds.nih.gov/disorders/primary_lateral_sclerosis/primary_lateral_sclerosis.htm
http://www.medicinenet.com/amyloidosis/page2.htm
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