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Neurology  (Expert Forum)
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Re: Bad lab errors??? What would you do???
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Re: Bad lab errors??? What would you do???

by CCF MD mdf, Jan 01, 1995 12:00AM
Posted By CCF MD mdf on July 27, 1998 at 13:04:36:

In Reply to: Bad lab errors??? What would you do??? posted by Susan on July 26, 1998 at 17:52:35:






I am a very complicated case as told by many doctors. I found some records that puzzled me one day and did finally approach my rheumy with these results on some
Porphyria tests done in 1996.  These are the lab reports and what would you say to do?
My doctors at that time ruled them bad lab errors...rheumie is having them repeated.
Performed by Mayo Medical Laboritories 200 1st St.Rochester, Mn.55905
TV=1900
24 hours  04-03-96
PORPHYRINS QUANTITATIVE,URINE
RESULTS:                                             NORMALS:
UROPORPHYRINS(OCTACARBOXYL)   H 29 UG/24 HRS         < OR = 22(FEMALES)
HEPTACARBOXYLPORPHYRINS          4 UG/24 HRS         < OR =  9(FEMALES)
HEXACARBOXYLPORPHYRINS           1 UG/24 HRS         < OR =  4(FEMALES)
PENTACARBOXYLPORPHYRINS         <1 UG/24 HRS         < OR =  3(FEMALES)
COPROPORPHYRINS(TETRACARBOXYL)H 165 UG/24 HRS        < OR = 60(FEMALES)
PORPHOBILINOGEN                  1.1 MG/24 HRS       < OR = 1.5(FEMALES)
=
There are various types of porphyria, which are distinguished clinically and by pattern of porphyrin abnormality. I don't know how to interpret the data given, especially out of clinical context. You have provided no information about symptoms and/or findings on physical examination.
Porphyria is rare, and neurologic complications are not seen in all patients. Typically, one expects a neuropathy, perhaps some patterns are more likely than others.
Porphyria is not a rheumatologic disease per se - usually one thinks of rheumatologists as dealing with disorders having to do with autoimmune mechanisms. Gastroenterologists and liver specialists are more likely to be experienced in porphyria, as it results from a fundamental problem with metabolism of heme type molecules.
Good luck. It probably isn't a bad idea to have the test repeated - it is not at all uncommon to find abnormalities which are actually errors or simply meaningless in the context of symptoms presented. I hope this helps. CCF MD mdf.

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