Re: Elevated CPK

Posted By Chad on April 22, 1999 at 09:13:52
I am a thrity year old male for the last three years my cpk's have been on the rise. It started out in the range of 900-1200 and with it a have muscle cramps and a low grade fever and migrans on top of all that.
ok now to date my cpk levels are around 2000-2200 had it higher on occasions had many blood test ruled out just about everything and muscal biopsy and the only thing i have come back with is Maligant Hyperthermia Syndrome.
So I'm asking if you have heard of Maligant Hyperthermia Awake Syndrom (syndrome) that seems the way my doctor is taking it at this point in time.
The medications that i am taking is Dantram at 75 mg,,
plese help with any way you can and if it is possible i would like to talk with others with long term elevated cpks...
Thanks,
  Chad sorry so breif at this time.

[CCF Neuro[P] MD RPS]

Posted By CCF Neuro[P] MD, RPS on April 22, 1999 at 10:57:28
Dear Chad:
Sorry to hear about your problem.  How did the diagnosis of malignant hyperthermia come about?  What did the EMG show?  Usually we only we high CPK levels when the muscle is abnormal.  Since all your tests have come back normal and I don't have the physical exam to note, what I am thinking is the possibility of a metabolic disorder, a mitochondrial problem.  The usual tests would not pick up this problem.  This disorders can be found in the context of a normal muscle biopsy.  Ask your physician to consider this entity, as it is associated with malignant hyperthermia, migraine, and muscle cramps.  The second suggestion is a calcium channelopathy.  This disorder has been associated with a type of malignant hyperthermia and migraine.  There is a genetic test for this entity, but it is only done in research labs.  I am not sure which research labs would run this test for you.  
Sincerely,
CCF Neuro[P] MD










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