Re: Neurotoxic Effects from Quinolones

Posted By CCF Neuro[P] MD, RPS on October 19, 1998 at 14:10:52:

In Reply to: Neurotoxic Effects from Quinolones posted by Jeanne on October 19, 1998 at 01:54:59:






Do you have any information on  Neurotoxic effects of Quinolones.
Especially realted to CNS disorders and resulting in some unusual Neuropathies with strange presentations?  I have a relative this happened to yet have been unable to find  information, if you can provide what you know or where I can access information thank you.
Dear Jeanne:
I am sorry to hear of your relative.  As you probably know already, the quinolones are also a GABA inhibitor (a neurotransmitter that balances the excitatory stimuli with a negative influence), in addition to it's antibiotic property.  The company recommends that this medication not be given to anyone with a pre-existing neurological problem such as seizures.  The more common CNS side effects are headache and restlessness that occurs in approximately 1-2% of those who take the medication.  There are some other CNS effects and these are many, but they are rare.  These include dizziness, lightheadedness, insomnia, nightmares, hallucinations, lethergy, drowsiness, vertigo, nervousness, confusion, manic reactions, toxic psychosis, irritability, weakness, tremor, ataxia, seizures, paresthesia, increased ICP, and depression.  Since quinolones are GABA inhibitors they probably should not be taken with other CNS stimulants like large doses of caffeine or theophylline.  There have been reported cases of patients resolving into status epilepticus and coma.  You can find this information about the above in the packet insert, the PDR, and likely your local pharmacist can give you a copy of the side effect list.  I hope this helps.
Sincerely,
CCF Neuro[P] MD, RPS