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Neurology (Expert Forum)
Re: quinolones reaction
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Re: quinolones reaction
by CCF Neuro[P] MD RPS, Jan 01, 1995 12:00AM
Posted By CCF Neuro[P] MD, RPS on January 22, 1999 at 12:39:21:
In Reply to: quinolones reaction posted by Sharon on January 21, 1999 at 22:36:06:
: On March 18th 1995, I was given a five day supply of Floxin at an urgent care center.By the 24th of March I was back at the urgent care center with a blood pressure of 120/160 and very blurry vision I have always carried a low blood pressure and do so now.I was given cipro because of blood in my urine, two days in to the cipro I experienced a sudden burst of pain on the left side of my head where there are tendons located, just above the base of my skull, I have experienced sever pain in that area, with severe dizzines(not vertigo). I have had a mri of the brain which was negative. the pain I felt wasn't like it was in the brain it was in the skull area.
: My question is since floxin and cipro can cause ruptures, Is it possible for that part of the tendon in the head have a rupture also.I have suffered terribly since taking floxin/cipro
: Linda
Dear Linda:
Sorry to hear about your problems. This class of medications can cause CNS stimulation, which may lead to tremor, restlessness, confusion, headache, and very rarely to hallucinations or convulsive seizures. They can also cause nausea, diarrhea, and rashes and rarely renal failure. There has never been a reported case of this medication causing tendon bursts (?). In young animals it can cause cartilege damage but this has never been found in humans to this point. You may be experiencing headache. I am not sure what the dizziness would be from, long term use can cause an anemia, but one would not see this with only 5 days of use. Sorry that I am not much help.
It is not likely that so many years have gone by with cipro inducing these symptoms. It is problably a better idea to try and figure out another etiology for these symptoms.
Sincerely,
CCF Neuro[P] MD
Dear CCf Neuros:
All PDR's and Drug inserts on this class of drug contain TENDON RUPTURE warnings/tendonitis etc.(these can happen during and after use) (see 20-40 studies that appear on Medline).
See the petition of 1996 to the FDA from Sidney Wolfe on Citizen's Organizations Website that elaborates on studies worldwide
regarding fluroquinolones and these adverse reactions. Hope this information will be helpful to you and anyone with a similar question.
You are correct, it was a post marketing adverse affect. In the first 29,000 doses of the quinolones this side effect was not seen. However, in the post marketing studies it was found. Sorry for my oversight.
Sincerely,
CCF Neuro[P] MD
In Reply to: quinolones reaction posted by Sharon on January 21, 1999 at 22:36:06:
: On March 18th 1995, I was given a five day supply of Floxin at an urgent care center.By the 24th of March I was back at the urgent care center with a blood pressure of 120/160 and very blurry vision I have always carried a low blood pressure and do so now.I was given cipro because of blood in my urine, two days in to the cipro I experienced a sudden burst of pain on the left side of my head where there are tendons located, just above the base of my skull, I have experienced sever pain in that area, with severe dizzines(not vertigo). I have had a mri of the brain which was negative. the pain I felt wasn't like it was in the brain it was in the skull area.
: My question is since floxin and cipro can cause ruptures, Is it possible for that part of the tendon in the head have a rupture also.I have suffered terribly since taking floxin/cipro
: Linda
Dear Linda:
Sorry to hear about your problems. This class of medications can cause CNS stimulation, which may lead to tremor, restlessness, confusion, headache, and very rarely to hallucinations or convulsive seizures. They can also cause nausea, diarrhea, and rashes and rarely renal failure. There has never been a reported case of this medication causing tendon bursts (?). In young animals it can cause cartilege damage but this has never been found in humans to this point. You may be experiencing headache. I am not sure what the dizziness would be from, long term use can cause an anemia, but one would not see this with only 5 days of use. Sorry that I am not much help.
It is not likely that so many years have gone by with cipro inducing these symptoms. It is problably a better idea to try and figure out another etiology for these symptoms.
Sincerely,
CCF Neuro[P] MD
Dear CCf Neuros:
All PDR's and Drug inserts on this class of drug contain TENDON RUPTURE warnings/tendonitis etc.(these can happen during and after use) (see 20-40 studies that appear on Medline).
See the petition of 1996 to the FDA from Sidney Wolfe on Citizen's Organizations Website that elaborates on studies worldwide
regarding fluroquinolones and these adverse reactions. Hope this information will be helpful to you and anyone with a similar question.
You are correct, it was a post marketing adverse affect. In the first 29,000 doses of the quinolones this side effect was not seen. However, in the post marketing studies it was found. Sorry for my oversight.
Sincerely,
CCF Neuro[P] MD
