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SERUM FERRITIN
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SERUM FERRITIN

SIR
I AM A DOCTOR DOING MY DISSIRTATION ON EFFECTS OF SERUM FERRITIN ON INSULIN SENSITIVITY. I WOULD LIKE TO WHETHER SERUM FERRITN HAS ANY INDIVISUAL EFFECT ON HYPERTENSION?



This discussion is related to Erythromelalgia and Ms symptoms.
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Hello Dear,
Serum ferritin is associated with increased risk of hypertension.
The following articles provide interesting insights.
What exactly is your study? Where is it being conducted?
Is it interventional or just an observational study?
What is the study design ?
Answers to these questions would be great.

J Hypertens. 2002 Aug;20(8):1513-8.
Increased serum ferritin is common in men with essential hypertension.

Piperno A, Trombini P, Gelosa M, Mauri V, Pecci V, Vergani A, Salvioni A, Mariani R, Mancia G.

Clinica Medica, Azienda Ospedaliera S. Gerardo, Università Milano-Bicocca, Monza, Italy. Alberto.***@****

OBJECTIVES : Insulin-resistance-associated hepatic iron overload syndrome (IRHIO) is characterized by high serum ferritin and presence of metabolic alterations that are part of insulin-resistance syndrome (IRS). Thus, clinical conditions characterized by a high prevalence of IRS may also be characterized by a high prevalence of IRHIO. DESIGN AND METHODS : We studied 88 consecutive patients with essential hypertension, 62 patients with IRHIO and 102 healthy normotensive controls. Hemochromatosis, other conditions able to induce secondary iron overload or serum ferritin increase unrelated to body iron stores were excluded. Iron indices, metabolic profiles and hepatic tests in hypertensive with or without increased serum ferritin and in IRHIO with and without hypertension were studied. Metabolic variables, serum iron indices, liver function tests and hepatic ultrasound data were analysed. Data were compared by non-parametric tests. RESULTS : In men with hypertension, increased serum ferritin was more frequent than in controls (21 versus 0%, P = 0.001). Hypertensive men with increased serum ferritin had more frequent and pronounced metabolic alterations than those with normal serum ferritin, the metabolic abnormalities and serum ferritin being frequently positively correlated. In hypertensive men with increased serum ferritin, metabolic and iron data were similar to those of IRHIO patients with hypertension. CONCLUSIONS : In males, hypertension is characterized by a higher prevalence of increased iron stores and metabolic abnormalities that are part of the IRHIO syndrome. This finding may have clinical implications due to the increased risk of IRHIO patients to develop hepatic cirrhosis and also for the role of iron in early atherogenesis.

Publication Types: Comparative Study

Increased serum ferritin is common in men with essential hypertension
Auteur(s) / Author(s)
PIPERNO Alberto (1) ; TROMBINI Paola (1) ; GELOSA Marisa (1) ; MAURI Viviana (1) ; PECCI Valeria (2) ; VERGANI Anna (1 3) ; SALVIONI Alessandra (1) ; MARIANI Raffaella (1) ; MANCIA Giuseppe (1 3) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Clinics Medica, Azienda Ospedaliera S. Gerardo, University Milano-Bicocca, Monza, ITALIE
(2) Divisione di Medicina II, Spedali Civili, University di Brescia, Milano, ITALIE
(3) Centro Auxologico Italiano, Ospedale San Luca, Milano, ITALIE
Résumé / Abstract
Objectives Insulin-resistance-associated hepatic iron overload syndrome (IRHIO) is characterized by high serum ferritin and presence of metabolic alterations that are part of insulin-resistance syndrome (IRS). Thus, clinical conditions characterized by a high prevalence of IRS may also be characterized by a high prevalence of IRHIO. Design and methods We studied 88 consecutive patients with essential hypertension, 62 patients with IRHIO and 102 healthy normotensive controls. Hemochromatosis, other conditions able to induce secondary iron overload or serum ferritin increase unrelated to body iron stores were excluded. Iron indices, metabolic profiles and hepatic tests in hypertensive with or without increased serum ferritin and in IRHIO with and without hypertension were studied. Metabolic variables, serum iron indices, liver function tests and hepatic ultrasound data were analysed. Data were compared by non-parametric tests. Results In men with hypertension, increased serum ferritin was more frequent than in controls (21 versus 0%, P= 0.001). Hypertensive men with increased serum ferritin had more frequent and pronounced metabolic alterations than those with normal serum ferritin, the metabolic abnormalities and serum ferritin being frequently positively correlated. In hypertensive men with increased serum ferritin, metabolic and iron data were similar to those of IRHIO patients with hypertension. Conclusions In males, hypertension is characterized by a higher prevalence of increased iron stores and metabolic abnormalities that are part of the IRHIO syndrome. This finding may have clinical implications due to the increased risk of IRHIO patients to develop hepatic cirrhosis and also for the role of iron in early atherogenesis.
Revue / Journal Title
Journal of hypertension   ISSN 0263-6352   CODEN JOHYD3  
Source / Source
2002, vol. 20, no8, pp. 1513-1518 (35 ref.)
(Ref: http://cat.inist.fr/?aModele=afficheN&cpsidt=13849246)

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