Dear Lawrence:
Sorry to hear about your father-in-law. I am assuming that the stenosis your talking about is internal carotid, and a 50% stenosis is not too worrisome at present. Some prognostic factors such as HDL level have been recently published but need to be repeated in other centers. The etiology therefore becomes important. I am not hearing that they did an MRI with diffusion weighted scan nor did I hear what symptoms your father-in-law had, that would tell me what sort of TIA he had. The recent a-fib is worrisome and hopefully they ruled out an intermittent a-fib event as the cause of his TIA (if so, then coumadin would likely be the best choice). If his vasculature shows stenoic lesions in the major vessels of the head then again likely coumadin would be best. If there is history of athrosclerosis then maybe ASA with or without pyrimadine or plavix might be the best. Liptor (liptor) might help if there is a high cholesterol level. If no etiology is known, then ASA alone is likely good enough. A lifestyle change will also be important as diet, excercise, etc become important. Find out the cause or etiology of the TIA and begin working on correcting that problem.
If you decide to come to the Cleveland Clinic for a second opinion, I would suggest Dr. Cathy Sila or Anthony Furlan (if it was my father, I would have them see him).
Sincerely,
CCF Neuro MD