Sumatriptan drug interaction

  I have been recently commenced on Zoloft (Sertraline HCI 50 mgs, 1 mane).   I get frequent migraine from my cervical spine problem and suffer from them prior to and after menstruation.  The migraine will often persist for days, and at times will continue on/off for 2wks.   I take Sumatriptan whenever the migraine reaches the unbearable stage.   Otherwise I manage with Mersyndol tabs and may add aspirin.
  The pharmacist warned me that Sertraline & Sumatriptan should not be used together.   I was advised to cease the Sumatriptan.   My GP wants me to continue with the Sertraline but has not suggested another choice of drug for my severe migraine attacks.    Something inplace of the Sumatriptan that may resolve the pain in a similar way.    What is your opinion regarding the interaction of these two drugs (Sertraline & Sumatriptan).   Can you suggest another medication that I might be able to take for my severe migraine attack.   I currently have sudden onset of hypertension, am on Propranolol  160 mgs, and chlorothiazide 500 mgs daily.   Under care of a physician for the > BP.    My GP was at a loss as to what could be prescribed for me.        
Dear Trisha:
Your pharmacist is correct, there is a theoretical risk in taking sumatriptan with sertraline (SSRI) as both might induce coronary vasospasm.  Both medications have a sympathetic action on the nervous system.  The Beta-blocker that your taking is known to be a prophaylic medication for migraine headaches.  How long have you been on this medication?  If only for a few weeks, then I would see if the B-blocker might help with your headaches.  You might increase the B-blocker dose and see if that might have an effect on your migraines.  Are you on the Zoloft for depression?  If so, you might stop the zoloft and switch to elavil or doxepin for your depression and migraine headaches.  Valproic acid has been shown to help in migraine headaches and also for some depressive disorders.  That would be another option.  It is impossible to give advice not having known your complete history and examining you.  These are only suggestions and would consult with your physicians.  Best of luck.
Sincerely,
CCF Neuro[P] MD, RPS