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Swelling in second and third toe in left foot

My question is what can cause your second and third toe to swell in the middle of night ?
I wake up with a ball in the middle of the metatarsal area. I went to two Orthopedic surgeons , had an MRI , onesaid possible arthritis , the other never got back to me .
I have been taking anti inflammatories , however issue is not resolved this  has ben going on for a few months . The one doctor gave me a cortisone shot , but I am still in pain, it feels like I am walking with a goolf ball in the middle of my foot.
thank you
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thanks
\I wil adress this to my neurologist
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Avatar universal
MEDICAL PROFESSIONAL
Thanks for using the forum. I am happy to address your questions, and my answer will be based on the information you provided here. Please make sure you recognize that this forum is for educational purposes only, and it does not substitute for a formal office visit with your doctor.

Without the ability to review your medical history and examine you personally, it is very difficult to determine whether or not  you have a neurologic condition. However, the neurologic condition that comes to mind when there is pain between the second and third toe is a condition called Morton's Neuroma.

The name Morton's neuroma seems to imply the presence of a neuroma, this is not the case, it is a misnomer. But basically the condition results from irritation, often due to compression of the interdigital nerves between the adjacent metatarsal heads or stretching of the nerves where they cross ligaments.

Symptoms often include pain or abnormal sensations in the forefoot. The pain may be sharp, burning, cramping. Numbness may be present in the toes around the area of pain.The pain with Morton's neuroma usually comes and goes; some patients describe the sensation of "walking on a marble"

Initial management of Morton neuromas is usually conservative, consisting of shoe modifications, physical therapy, use of types of pads or orthotics to prevent the movements that make the irritation worse (basically, when the "toes are brought to the nose", when the foot and toes are lifted up toward the ceiling, nerve irritation gets worse) and steroid injections. Surgical intervention is sometimes necessary.

Tight shoes worsen the nerve compression and should be avoided, this may alone relieve symptoms.

Again, I am unable to determine based on the information you have provided whether or not your toe problem is neurologic, but it may be helpful for you to be evaluated by a neurologist.

Thank you for this opportunity to answer your questions, I hope you find the iformation I have provided useful, good luck.
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