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Dear Donald:
Sorry to hear about your trouble sleeping. You are correct about FFI and other prion diseases implication in sleep disturbances. However, although they are implicated the usual rapid pace that these diseases usually proceed would rule these entities out in your case. These entities also have the symptoms of hallucinations, myoclonus, cortical spongiosis, ataxia, and profound mental status changes. Yes, I think that thalamic processes might affect sleep, as we think that sleep spindles seen in stage II sleep are from the thalmus. But this is a theoretical thought. We know that patients with thalamic stroke have pain problems, difficult in initiating events, memory problems, disturbed consciousness, motor and sensory impairments etc. all depending on the locations within the thalamus. As you do not describe any of these symptoms, I doubt that you have a thalamic lesion. My suggestion, would be to see a sleep expert and have some testing performed. As you know, a good nights sleep is worth it's weight
in gold.
Best of luck, I hope I answered you questions.
Sincerely,
CCF Neuro[P] MD