Here is a quick synopsis of sx history: DEC98-loss of lower peripheral vision, optic pallor, pappilladema rt eye(OD) - dx Optic Neuritis (later vacated)-tx wait and see; MAR99-altitudinal visual field loss(VFL), eye pain, optic pallor OD-tx 2.5 weeks oral steroids (20mg daily); JUN99-5% increasing to 85% VFL left eye(OS) in 3 week period, 15% VFL upper peripheral OD, weakness/fatigue-dx severe anemia and AION-tx 2 units whole blood, 4 days IV and 3 months oral steroids 40mg daily, steroid support meds, iron tablets-tests extensive blood work (anemia otherwise normal), CT scan & 2 MRIs (brain and orbits)(all normal), LP(opening pressure(OP) 220), bone marrow biopsy(leukoerythroblastic smears(later cleared)); MAR00-VFL progressed from steroid-restored level(altitudinal loss both eyes, severe optic pallor,no cupping, 30% scotoma central and upper OS) by 35% OS & 15% OD, weakness/fatigue, muscle & joint pain, fasciculations-dx optic atrophy unknown etiology & anemia-tx 3 day IV and 3 week oral steroids 60mg daily, iron-tests LHON mitochondrial screen, MRI, and redux of blood work(normal);FEB01-VFL progressed from steroid-restored level(<10% increased VFL from previous level) by about 30% OS & 20% OD, increase of previous sx, balance problems-dx optic atrophy(AION vs ON), anemia cleared-tx Avonex (empirical prescription by Neuro) for 6 months-tests LP(OP 221); JUL01-no progression VFL, cognitive problems(subcortical), tremors, myoclonus, and previous sx-dx optic atrophy unknown neuro-tx halt Avonex-tests neuro-psych, vestibular, VEP, LP(OP 90). Wish for any ideas you might have.