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306259 tn?1204773075
Upper motor neuron
My daughter (16) had a positive Babinski response on right foot only.  Has constant headache (lower back of skull) for last 6 mos, along with tingling/numbness in face, constant nausea, Occasional seizure like episodes (seems like absence seizures but not verification with EEG), and Orthostatic Hypotension with normal blood pressure at 100/58.

If Babinski response indicates upper motor neuron issue, possibly lesion:

Question:  What happens next if not seen on MRI?  and if seen on MRI, what is done for a lesion?

Note:  all other neuroloigcal test normal.  All bloodwork normal.  Spinal Tap normal.  MRI & MRA normal (other than large globular pituitary which endo says normal for teen).  Lyme, Heavy metals, hormones, ANA- all normal.


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306259 tn?1204773075
DO NOT listen to this "dr logan".  The website that he is stating is just a generic drug sales site.  I did report his comment.
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I'm not a neurologist, but am an early Medical student.  Just had a read of your post and I'm learning about neuroanatomy at the moment.  Using my minimal knowledge...

The postural hypotension could be due to an enormous range of things, but, as you say an enlarged pituitary.  Among other hormones, the posterior part of the pituitary produces ADH (Anti Diuretic hormone), which serves to retain body water and maintain the volume in the blood (i.e. keep blood pressure up).  Innervation of posterior pituitary may be comprimised.

Tingling/Numbness in face - Trying to relate this to the constant headache in the back of the skull - the corticobulbar fibers (involved in facial innervation, jaw movements and swallowing) - runs through the superior cerebral peduncles, which exist on the anterior side of the mid-brain of the brain stem.

Ask your neurologist to look at the neuroanatomy surrounding the cerebral peduncles and innervations of the posterior pituitary.  They're all generally on the anterior (front) side of the brainstem.
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Oh, a blood test looking at oxytocin levels (also produced by posterior pituitary).  If they're reduced, then possible clue that posterior pituitary is not functioning right.
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http://www.merck.com/mmpe/sec12/ch151/ch151b.html

Pituitary lesions...something to bug your neurologist about...especially the description of Empty sella syndrome.
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306259 tn?1204773075
Thank you for your comment.  We just left another pediatric Endocrynologist and he said the same as the others:  If hormones are okay then she does not have an endo problem.  Her ACTH level is very high, but he said that because she is VERY slim this could not be the problem.  (She has a barbie doll figure).  He is sending her to another pediatric Neurologists.  I am just about to give up.  No one will look at the whole issue.  Each doctor deals with only the symptoms that may be related to their field.  Thanks for the input.  I will try to get the info to her new Neuro when she sees her in July.
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