Zofran for Tardive Dyskinesia

[ILADVOCATE]

I am considering the use of Zofran for tardive dyskinesia. I have developed severe forms of tardive dyskinesia from tardive myoclonus to tardive psychosis (this condition itself is still under investigation but a psychiatric researcher from Columbia will be following it up). I acquired this condition from the long term use of antipsychotics but was unable to tolerate Clozaril and am on an experimental antipsychotic in FDA study glycine under the care of a psychopharmocologist. However, despite the full mental recovery, the neurological disorder has been debilitating including full body spasms and weight loss and psychomoter agitation (all other conditions have been ruled out, EEG's and Catscans were done). I am on Methocarb, Skelaxin and Flexaril and Klonopin which even at maximum doses provide only limited control as well as a natural remedy rhodiola, which is in clinical study but as it is not isolated as a compound can provide only limited relief. I was unable to tolerate all anti Parkinsonian agents because they enduced psychosis as well as alpha blockers such as Clonidine because they enduced suicidal ideations. Has Zofran been regularly used as safe and effective for Zofran? What are the side effects? And also given I read it helped psychosis from Parkinson's could it help what is being studied as tardive psychosis. I understand some of these questions are complex but given that the tardive conditions cause respiratory convulsions and myoclonic spasms any idea that its been of some use would be of great help to me. I was ruled out for use for Xenaxine because of its potential to cause depression but I am in need of some treatment and any medication that would actually help with Parkinson's related psychosis (I understand it was in study as an adjunct to conventional antipsychotics as well) might be beneficial to me. You can give some answers as to what you are familiar with as I understand my case is complex but any information that would show it could be of use and what to expect would be of great help to me. Thank you.

[DrNoopurMD]

Hi,

How are you?
Zofran or ondansetron is a 5HT3 antagonist. An open label trial found zofran to be very useful in antipsychotic induced tardive dyskinesia.
The study showed significant improvement in the disease’s symptoms. Headache, constipation, and dizziness are the most common adverse effects.
Hope this information is helpful.

[ILADVOCATE]

Thank you. I'll speak to my neurologist about it.