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Neurology (Expert Forum)
Zyprexa and decreased risk of neurological symptoms
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Zyprexa and decreased risk of neurological symptoms
by E-Gren, Oct 03, 1998 12:00AM
I have been taking Zyprexa for two weeks. Though it is usually indicated for people with schizophrenia, my psychiatrist informed me that it has also proven to be effective for people suffering with major depression characterized by muddled thinking and poor memory, such as myself. He was right on target! I have experienced a kind of clarity that has made me continually recall the book (and movie), "the Awakenings"
My question is, what sets this medication apart from the other major psychotropic medications? I have heard that there is a decreased risk of T.D and the other unfortunate adverse reactions that often accompany usage of the other drugs in this class.
Also, I have been in the "wait and see" group for M.S after an episode that suggested scattered CNS involvement (dizziness, tinnitus, parasthesias, light sensitivity) All symptoms have remitted - I have been symtom free for 4 months now. However, given my uncertain status, should there be any additional concerns taking this medication?
Thank you for your valued time!
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Thanks for your question. The following is a quote from the Zyprexa's
(Olanzepine) manufacturer literature:
"Olanzapine is a selective monoaminergic antagonist.
The mechanism of action of olanzapine, as with other antipsychotic drugs,
is unknown. However, it has been proposed that this drug's
antipsychotic activity is mediated through a combination of dopamine
and serotonin type 2 (5HT2) antagonism. Antagonism at receptors other than
dopamine and 5HT2 with similar receptor affinities may explain some of
the other therapeutic and side effects of olanzapine. Olanzapine's
antagonism of muscarinic M1- 5 receptors may explain its anticholinergic
effects. Olanzapine's antagonism of histamine H1 receptors may explain
the somnolence observed with this drug. Olanzapine's antagonism of
adrenergic alpha1 receptors may explain the orthostatic hypotension
observed with this drug."
Amongst the possible side-effects of this medication are: orthostatic
hypotension, interference with cognitive and motor performance, transient
elevation of liver enzymes. It also recommended that patients inform their
physicians if they become pregnant.
Regarding your current MS evaluation, there is some overlap between possible
side-effects of this medication, and MS symptoms, so the physician who is
evaluating your neurological symptoms should be informed about your current
list of medications.
I hope this information is helpful. Best of luck.
