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complete dopaminergic shutdown
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complete dopaminergic shutdown

I need to know if regrowth of dopamine receptors is possible in humans in the frontal cortex, striatum, hypothalamus, nucleus accumbens if they were all destroyed somehow by a contaminated illicit substance, which caused total fixed insomnia, complete anhedonia throughout the limbic system, and bad tinnitus.

4 months later of which no recovery was evident other than a little bit of cognitive recovery.

There was initially a little body movement abnormality which improved over a month.

Vascular tone, cns shutdown / possible damage added to this through supposed amyl nitrate use. Which has moderately recovered, leaving vascular tone issues in the legs and possible dopamine reduction also as well as damage to serotonin transport, which seems partially recovered.

There seems little to no recovery of dopaminergic function in the limbic system.

The fixed insomnia is a real physical symptom, not imagined, and there seems questionable possibility of dopaminergic recovery from complete destruction.

The substances which caused this are not entirely known for certain.

It is assumed 5-htp powder, and cocaine, meth or Mephedrone with contaminant at a dosage of 10grams within 24hr period. Caused intense brain stem damage, resulting In depression, loss of mental facultys, tinnitus and brief serotonin syndrome upto 2hours after. Then over the next 12 days there was a gradual loss of dopaminergic transport resulting in complete anhedonia, loss of male brain orgasm.

One month abstinence from all substances resulted in no recovery.
After this month of abstinence 3grams of intranasal crystal substance was consumed along with one large inhaled dose of amyl nitrate. This caused complete destruction of ability to sleep which persists 4months later along with previous mentioned symptoms.

Is there any chance of identification of contaminants. Or would the suggested substances cause described effects at reported dosages?

If there is no recovery of dopaminergic function 6months after the events,   what is the reality of transplantation of dopamine receptors into the striatum, nucleus accumbens, and frontal cortex, hypothalamus for recovery of sleep function and orgasmic ability as well as brain function recovery.

In rats, if over 90% of dopamine receptors are destroyed there is no recovery.
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Avatar_dr_m_tn
Thanks for using the forum. I am happy to address your questions, and my answer will be based on the information you provided here. Please make sure you recognize that this forum is for educational purposes only, and it does not substitute for a formal office visit with a doctor.

Without the ability to examine and obtain a history, I can not tell you what the exact cause of the symptoms is. However I will try to provide you with some useful information.

Dopamine is a major neurotransmitter in the central nervous system. There are several dopamine projections and if disturbed can cause neuropsychiatric and/or movement disorders. One pathway is the nigrostriatal pathway which is affected in parkinsonism disorders. Another is the mesolimbic pathway which has a key role in the positive symptoms of schizophrenia, hallucinogen use, and temporal lobe epilepsy. Mesocortical pathway is involved in information processing, attention, and wakefulness. Lastly, tuberoinfundibular system is involved in secretion of prolactin.

For any of these pathways to function normally after insult, it will ultimately be determined on the insult and severity of the insult. Many drugs have been developed to replace dopamine within the central nervous system. Also, surgery (i.e., deep brain stimulation) has also been used to improve symptoms associated with these pathways. Regrowth of injured pathways has been suggested in the medical/research literature.

Thank you for this opportunity to answer your questions, I hope you find the information I have provided useful, good luck.

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Avatar_f_tn
hi. thanks for the reply.

a lot of the cns functions in my body are returning. for example I lost the ability to cry tears and my eyes were dry for a month or 2, along with no emotional feelings in the abdomen. these have recovered substancialy.

I have read that serotonin dendrites can make recovery even after major insults and Infact grow back to supranormal levels.

would the dopamine receptors be able to make a recovery with this deep brain stimulation even if the insult was severe?

one more question....    if the insult damaged cochlear functions for balance... is this system ever known to make a recovery after an insult? or would it be lost permanently?

Thankyou.
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