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Neurology (Expert Forum)
oligodendroglioma-Treatment-
This forum is for questions and support regarding neurology issues such as: Alzheimer's Disease, ALS, Autism, Brain Cancer, Cerebral Palsy, Chronic Pain, Epilepsy, Fibromyalgia, Headaches, MS, Neuralgia, Neuropathy, Parkinson's Disease, RSD, Sleep Disorders, Stroke, Traumatic Brain Injury.
oligodendroglioma-Treatment-
by Joseph-Thornhil, Nov 14, 1998 12:00AM
My wife (Debbie) was diagnosed with a low grade oligodendroglioma
in Sept. of 1991. She had sugery on the 5th of that month followed
by 6 weeks of radiation. An MRI with Gad. on Sept. 14th of this year showed the tumor in the beginning stages of recurrence. A follow up
MRI on the 14th of Oct. showed no change in size or other areas
effected. The tumor was located in the left frontal lobe near the top.
In the first surgery it was not difficult to get to. A second sugery is
scheduled for the first week in January of 1999. Our Neuro-Surgeon
Dr. J A Bermudez indicated that Chemo was not effective on this type
of tumor, I have seen other articles on the web that may indicate differently.
Has immunotherapy been proven to be effective?
Thank you
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Traditionally oligodendrogloimas have been thought not to be sensitive to chemotherapy however there is growing evidence that some subtypes at least may be partly responsive.
I have attached some references which explore the question.
To rewiew these options in detail you may wish to consult with a neuro-oncologist, a neurologist who specialises in the non-surgical treatment of brain tumors , usually in conjunction with a neurosurgeon.
trials ore ongoing in immunotherapy but definite conclusions are not yet available.
Friedman HS. Lovell S. Rasheed K. Friedman AH.
Duke University Medical Center, Durham, North Carolina 27710, USA. Fried003:mc.duke.edu
Treatment of adults with progressive oligodendroglioma with carboplatin (CBDCA): preliminary results.
Medical & Pediatric Oncology. 31(1):16-8, 1998 Jul.
CONCLUSIONS: Carboplatin appears to be active in the treatment of adults with progressive oligodendroglioma
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Allison RR. Schulsinger A. Vongtama V. Barry T. Shin KH.
Roswell Park Cancer Institute, Buffalo, NY 14203, USA.
Radiation and chemotherapy improve outcome in oligodendroglioma [see comments].
International Journal of Radiation Oncology, Biology, Physics. 37(2):399-403, 1997 Jan 15.
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Peterson K. Paleologos N. Forsyth P. Macdonald DR. Cairncross JG.
Department of Neurology, University of Minnesota, Minneapolis, USA.
Salvage chemotherapy for oligodendroglioma.
Journal of Neurosurgery. 85(4):597-601, 1996 Oct.
“ the synergistic of VP-16 and CDDP may exert substantial anti-oligodendroglioma activity, and it warrants further evaluation. “
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