pernicious anemia or MS

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  6 years ago was diagnosed with MS based on abnormal MRI but evoked potential and lumber puncture were negative.
  Last year, it turned out that my diagnosis of pernicious anemia "fell in crack 6 years ago" as told by doctor.
  Because my B-12 level was low 6 years ago and he had not paid attention to my low level of B-12.
  Schilling test and antibody test confirmed pernicious anemia.  Could B-12 cause abnormal MRI scan.
  How probable is it to have both MS and PA?  How probable is it to get new nuro symptoms even though I take B-12 shots monthly?
  I am 36 years old male from Middle East. Thanks.
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Thank you for your question.  The most common neurological lesions from
vitamin B12 deficiency are observed in the white matter of the spinal
cord, that is, affecting primarily the axons (the conduits) of the
nervous system.  As a result of these lesions, patients usually complain
about altered sensation in hands and feet.  Weakness and unsteady gait
are also frequent symptoms.  The peripheral nerves are also affected with
loss of axons.
Although less common than the lesions in the spinal cord and in the
peripheral nerves, similar lesions can be seen in the white matter
in the brain, resulting in the abnormal MRI scan that you mentioned.
I am not aware of any association between MS and Vitamin B12 deciency.
With adequate treatment, one can expect at least partial improvement
of the symptoms, and most the improvement will occur during the first
6 months of therapy.
This information is provided for general medical education purposes only.
Please consult your doctor regarding diagnostic and treatment options.