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polio vs parkinsons

polio vs parkinsons

my mother had polio as a child, now at 76 she is experiencing symptoms of parkinsons,
she has been on wellbutrin for about 8 years.
I am a family Nurse Practitioner, so feel lost, No one weems to be looking at this as a whole.
Where do I begin.
She has had MRI which was negative
She was started on Sinemet but her falls have increased- this past week she feel and hit her head, he falls are presenting quit differently from previous falls.
Please help with suggestions.
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Avatar_dr_m_tn
Dear,

Carbidopa is dopa decarboxylase inhibitors. They help to prevent the metabolism of L-dopa before it reaches the dopaminergic neurons and are generally given as combination preparations of carbidopa/levodopa (e.g. Sinemet) There are also controlled release versions of Sinemet that spread out the effect of the L-dopa. Duodopa is a combination of levodopa and carbidopa, dispersed as a viscous gel. Entacapone inhibits the COMT enzyme, thereby prolonging the effects of L-dopa, and so has been used to complement L-dopa.
The dopamine-agonists bromocriptine, pergolide, pramipexole, ropinirole , cabergoline, apomorphine, and lisuride, are moderately effective.
Selegiline and rasagiline reduce the symptoms by inhibiting monoamine oxidase-B (MAO-B), which inhibits the breakdown of dopamine secreted by the dopaminergic neurons.

Best
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Avatar_f_tn
How can you differentiate between post polio , parkinsons and parkinsons iduced by use of wellbutrin?
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Avatar_f_tn
I, too had polio in 1954 and have been diagnosed with post polio syndrome.  Now my doctor is treating me for early parkinsons, even though I don't have the classic symptoms - I do have tremor (not at rest) and have had for several decades, but I also have two aunts with essential tremor which looks identical to what I am experiencing.  I don't have any rigidity or other symptoms.  A recent knee replacement has stabilized my tendency to trip over things, which is classic post-polio.  I'm very interested in daughterwithquestions most recent question:
How can you differentiate between post polio , parkinsons and parkinsons induced by use of wellbutrin?  I feel strongly  that parinkinsons is a misdiagnosis in my case, and I need more details.
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