I also have severe RLS and the only medication that has ever worked for me is Requip. It is an anti parkinsons medication but was studies and labeled for the treatment of RLS a few years ago. It works miracles and I haven't had any problems becoming tolerant of the dose I am on. I've been taking it for several years. You do have to start at a low dose and titrate up to a therapeutic level. I take 1 mg at bedtime.
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