[ Follow Ups ] [ Post Followup ] [ The Neurology Forum ] [ FAQ ]
Posted by CCF Neuro MD on July 13, 1997 at 21:59:43:
In Reply to: tegretol xr posted by Jane on July 05, 1997 at 23:42:43:
Does anyone know how tegretol xr (extended release) works for trigeminal neuralgia? Been taking tegretol for it and having a rough time of it. Wondering if the extended release is any better. Love a response! Thanks.
Tegretol has been widely accepted as a first line medicine in treating trigeminal neuralgia. About 75% of patients respond. How it works has been a research focus for quite long time. Up to now, it is still unclear of the exact mechanism of action. One of the thoughts is that since trigeminal neuralgia is associated with hyperstimulation and hyperactivity of the branches of trigeminal nerve, a cell membrane stabilizer like tegretol would work well.
As far as the side effects, vertigo, drowsiness, and unsteady gait (ataxia) are the commom ones. In addition, double vision and diarrhea are also sometimes reported by patients. In general, all the side effects are more frequent to occur in elderly patient population. The way to derease the frequency of side effects is to start the medication slowly, 50-100 mg to start with then gradually go up as tolerated. Therapeutic doses generally range from 600 to 1200 mg per day. Once the pain is controlled completely, the dose can be decreased gradually to the pain free level. If someone is not tolerating the side effects of tegretol, or not pain free with therapeutic level, there are other drugs to choose, including dilantin, baclofen, and clonazepam.
Unfortunately, I was not able to locate any well controled study that compared regular with extended release form of tegretol on the effectiveness of treating TN. I will share that with you if anything comes up later.
This information is provided for general medical education purposes only. Please consult your physician for the diagnostic and treatment options of your specific medical condition.
The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. Med Help International, Inc. is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. We offer this Site AS IS and without any warranties. By using this Site you agree to the following Terms and Conditions. If you think you may have a medical emergency, call your physician or 911 immediately.