weak muscles

I am a 41 yr old female.I have Hashimoto's disease. my thyroid levels are now under control.  i am  experiencing major fatigue, my leg muscles wont let me stand long due to weakness, i have insomnia, i have not been able to work since march.  my nero doc has ran an mri which showed normal. an emg which showed muscle deteriation, 2 muscle biopsies which showes muscle degeneration, a genetic opmd and myotonics which came back neg. i have been tested for myastia gravis and was neg. lupus which was neg. my tpo runs high, my ck within normal range. my nero doc thinks this is some sort of rare autoimmune disease.i have been ill since feb of 2002. my biopsys have showed neg for polymyositis, but i have been told that some muscles show it and some dont.  also when i was a child i was one of the children that it became mandatory on to take the rebulla vaccine. after taking it i was hospitalized for 2.5 weeks with paralyzed legs. and had a hardtime walking for a long time. could this have layed dormat and came out? i am just trying to find an answer so i can get treatment and live my life.  thank you

[CCF-Neuro-M.D.-JT]

It's extremely difficult to try and form an accurate neurological opinion regarding your complex case having never reviewed your studies personally.  Some of the various results from your extensive testing are patchy and conflicting. For instance, there's a very big difference between a primary muscle disease and polio. If you've had polio (which is a spinal cord disease, NOT a muscle disease), it should show up on the EMG with a specific pattern even if you had it about 50 years ago (which is when the polio epidemic took place in the US, so you're a bit young to have had it unless you were overseas). If the EMG shows primary muscle disease and no evidence of polio, then that should be ruled out completely.  Immune causes for a myopathy (muscle disease) are certainly a possiblity as well as thyroid disease or other metabolic causes.  One thing to consider is to see an academic neuromuscular specialist who can help you sort things out, put all the clues together, and get definitive testing so that the proper diagnosis is made and treatment initiated. If you're in the area, Drs. Kerry Levin and Robert Shields are outstanding neuromuscular specialists who would be happy to see you. Slides from your biopsy should be brought or sent to an academic neuropathologist or at least sent to AFIP for a second review.  This may be also be helpful.  Good luck.

[J1932G27]

A related discussion, LIPITOR REACTION was started.

[sohail66]

A related discussion, Muscle Stretch was started.