Hi there. I'm not the best person to answer this question. I have taken Prozac with success in the past. Currently I take a different drug. BUT I also take folic acid to counter the effects of methotrexate for RA and I don't feel it has had any effect on making my OCD worse. Honestly, over the counter medication I have not had much success with. I think the first thing to do is learn cognitive behavioral therapy and then if you are still having problems, then you can introduce medication. Medication works well but there will always be times of breakthrough anxiety and that is where the CBT comes in handy.