Two years ago I began experiencing pain in my right wrist. There was no acute onset and the pain would come and go, sometimes lasting a month or more before going away and not hurting again for several weeks. It would hurt when the hand was in a neutral position as well as if I flexed it and applied pressure (like, pushing a door open). The source of the pain is in a groove between the wrist and the hand, at approximately the 2nd and 3rd metacarpals. After several x-rays and an mri, the doctor said he "thought" I had a ganglion cyst at that location and injected it with cortisone to hopefully shrink it. As I left the doctor's office, the injection site was sore but I thought nothing of it. However, by the time I returned home, the pain was excruciating. I could not do anything with my hand, wrist, or arm. It was even too painful to place my wrist on my body as I lay in bed. The pain persisted for at least 24 hours and was so bad I had to write with my left hand the day after the injection. Nothing (NSAIDs, ice, elevation) helped the pain. Is this an indication of an allergy or did the doctor hit a nerve or something?? Also, the pain from the shot subsided but 6 months later my wrist pain is exactly the same as it was before; there was no relief. Any ideas what is going on? Thanks!