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Ovarian Cancer (Expert Forum)
Chemotherapy for 1st relapse
Answered by
Annekathryn Goodman, M.D. - Gynecologic Cancers, Complex Gynecologic, Surgeries, Palliative Care, Acupuncture
Massachusetts General Hospital Cancer Center
Boston - MA
Chemotherapy for 1st relapse
by OVCIndia, Nov 04, 2009 12:52PM
Diagnosed with Stage IV Grade 3 OVC in Nov 2007 with CA 4900
Neoadjuvant chemotherapy with Carboplatin and taxol with Complete cytoreduction and 3 cycles of consolidation IP Cisplatin.
3 Months after treatment CA went down to 9.8 and CT came in clear
6 Months after treatment CA was at 10.1 and CT came in clear
9 Months after treatment CA came in at 27.
12 Months after treatment CA came in at 51.
PET/ CT which showed multiple peritoneal deposits including the surface of the liver and around the colon. Oncologist recommended no surgery but re-treat with chemo.
Started on Doxil and Carboplatin based on treatment plan as per Calypso Trial. 3 cycles after chemo CA125 came in at 7.5.
In such a setting does one stop chemo once the CA125 normalizes or continue for the full 6 cycles.
Thanks
OVCIndia
Neoadjuvant chemotherapy with Carboplatin and taxol with Complete cytoreduction and 3 cycles of consolidation IP Cisplatin.
3 Months after treatment CA went down to 9.8 and CT came in clear
6 Months after treatment CA was at 10.1 and CT came in clear
9 Months after treatment CA came in at 27.
12 Months after treatment CA came in at 51.
PET/ CT which showed multiple peritoneal deposits including the surface of the liver and around the colon. Oncologist recommended no surgery but re-treat with chemo.
Started on Doxil and Carboplatin based on treatment plan as per Calypso Trial. 3 cycles after chemo CA125 came in at 7.5.
In such a setting does one stop chemo once the CA125 normalizes or continue for the full 6 cycles.
Thanks
OVCIndia
Doctor's Answer
by Annekathryn Goodman, M.D., Nov 26, 2009 07:38AM
, Nov 26, 2009 07:38AM
Hi There
I agree with the plan to continue chemotherapy. There are sometimes where one just stays on the chemotherapy if the side effects are not too hard. The chance of the cancer recurring once chemo is stopped is very high.
thank you for the update
best wishes
I agree with the plan to continue chemotherapy. There are sometimes where one just stays on the chemotherapy if the side effects are not too hard. The chance of the cancer recurring once chemo is stopped is very high.
thank you for the update
best wishes
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PET/CT findings
Hepatic nodules could not be visualized, significant reduction in size diaphragmatic nodule, interval reduction in peritoneal deposits. No new lesions found. Consider Good response to chemotherapy.
Her oncologist said that she has had a very good response and though her CA is normal he will continue with Doxil and Carboplatin as per Calypso Trial protocol.
Have you seen a good outcome in this setting?
Can chemo alone clear all the tumors in the abdomen?