Doxil/Clinical Trial Phase II

Saw the Dr. at MD Anderson and then to check into a clinical Trial Phase II. The drugs were similar to Avastan, blocking the blood vessels to the tumor. I may not be qualified due to my broken leg. My blood vessels to my leg would also be compromised. If that does not pan out, he thought I would be on Doxil. Has anyone been on Doxil? Success?  Side Effects?  I am Stage II, 54, and one 7cm tumor pressing on my colon. The tumor grew 1 cm while on Carbo/Taxol over 9 weeks.

[jane65]

Hi Conners,
I hope you get into that clinical trial, I hear such good things about Avastin and a similar working drug should be a good treatment choice for you.

It's a shame that the broken leg might disqualify you from the trial, maybe your oncologist can give you Avastin under his care.

I haven't had Doxil, so I can't help you there but I know a lot of the ladies on the forum will be along with their experiences.

Good luck and feel well,
Jane

[Tealoak]

I started a trial at MD Anderson last week with Doxil, Avastin and Torisel ( mTOR inhibitor)--all 3 drugs week one; Torisel on week 2 & 3.  My Gyn-Onc originally did not think I would qualify because of blood clot issues, but the clots are stable and I qualified for the above trial as well as the Taxotere/VEGF-Trap and Taxotere/Perifosine.  The Taxotere/VEGF-Trap trial appeared to be the most picky for qualifying.

So far the drugs are a breeze with the exception of mouth sores. I picked up some "magic mouthwash" today after my chemo.  It should help.

I am stage 4 clear cell with progression on first line chemo; liver mets doubled in the month off of chemo while getting some dental work done.  Obviously I am really hoping this clinical trial will work. sigh.

Teri Jakob

[jane65]

Hi Conners,
I left you note, I don't know if you saw it or check your notes on this forum, so I thought I'd let you know here.
Jane

[jane65]

Hi Teri,
Good luck with your trial drugs, it sounds promising.
Jane

[Teresa222]

By any chance is your OVCA Clear Cell? Again, please complete your Profile so that we will know exactly where you are coming from at this stage in your battle. Check some of the other ladies Profiles if you need to see how we complete them.
Thanks~!
Teresa