Endometrial Adenocarcinoma in mother w/no female organs

I'm not sure if this is the right forum to post this in, but it's the closest I could come to.  My mom was recently diagnosed with adenocarcinoma, which her doctors think is endometrial cancer.  What makes this so strange is, she had a hysterectomy in her 30's (she's 72 now), due to severe endometriosis.  They said what makes he case so unusual is, she has no female organs and hasn't for decades.  On top of the mass in her pelvic floor, these is also a mass near the bladder and a mass, which is possibly metastised on her hip.  She has had a PET scan, bone scan, and a biopsy of the main mass in the pelvic floor.  She is due to have a biopsy of the hip, which will help determine if all three masses are related, if the hip is truly metastised and what stage the cancer is in.  My question is, they are telling her it is going to be stage 2, 3 or 4, but even if it is stage 4, it is very curable.  However, everything I have read about this kind of cancer says it has a very high morbidity rate, if it has spread to other areas of the body, primarily bladder, colon, etc.  As I stated above, she has a second mass near the bladder and a third on the hip.  Her MRI report said the hip mass had already metastised, but they want to do the biopsy to find out..  She is going to be treating at the City of Hope.  Can you please give me an idea what in fact the morbidity rate is, since I am getting conflicting info?  Also, could something like be hereditary?  I do have PCOS, infertility, etc.  Thanks.  

[Annekathryn Goodman, M.D.]

Hi there
if you Google "pubmed" and then click on pubmed home

then in the search box write "cancer arising in endometriosis after hysterectomy"

you will pull up many articles of this phenomenon
As an oncologist, I see this frequently.

Women have a hysterectomy and removal of ovaries  for cancer of the uterus (endometrial cancer) years later a new cancer is identified. Biopsy suggest similar looking cells to the cancer from the uterus.

there are 2 possible interpretations:
the original cancer has recurred or a new cancer has started in an implant of endometriosis.

for your mother, she did not have cancer of the uterus. But she had severe endometriosis.

despite decades of menopause, those endometriotic implants can still transform into a malignancy. It is thought (but not proven) that estrogen stimulation causes these endometriotic implants to grow:

either from estrogen replacement therapy or from estrogen  made by the body (for example women who are overweight make estrogen from their fats cells and are at higher risk for developing endometrial cancer and breast cancer)

prognosis will depend on whether it is possible to either surgically remove the masses or give effective chemo-radiation to destroy the tumors

City if Hope has a great cancer center. She will be in good hands
take care