CA125 was 296 pre surgery 195 pre chemo and dropped to 95 two weeks after 1st chemo then 2 weeks after 2nd round dropped to 18.9 My sister needs a temporary colostomy for recto-vaginal fistula. She is stage 2C, Endometrioid, grade 3 with a pelvic mass before chemo that seems to have responded very well. I believe the surgery would extend chemo interval to 5 weeks, laproscopic. She would also benefit from 2nd look. Her Dr. says it is up to her when to have surgery so I am asking is it safe after say 3 or 4 chemos or better to wait after 6. She can't sit and pain are reasons for early surgery. Possibility for pelvic radiation after surgery to cul-de-sac if disease still present? Also will CA125 change much from say 2 weeks after chemo to day of chemo? Thanks.