Glandular Cells found in Pap

I have HPV and had a Leep done 2-3 years ago - the f/u Paps for the next 18 months were clean, but I had not had a Pap for 14 months until 2 weeks ago.  My doctor called and said they found glandular cells.  She's going to do another Pap and a biopsy on the 27th of this month.  The Pap was done 5 days after my period started so she thinks it's possible it's just left over period cells.  My question is, given my history, what is the probability that it may be cancer of the uterus or cervix?  What are the odds of having either??  Any info is appreciated.  thanks!

[Annekathryn Goodman, M.D.]

Hi There,
here is a nice link to a paper on atypical glandular cells on papsmear. In general there is a 40 % change of hae some abnormality although the majority of abnormalities are very mild (mild dysplasia /low grade lesion) and chance of cancer less than one percent.
best wishes

http://www.medscape.com/viewarticle/490056

Abstract
To determine the incidence of clinically significant lesions in high-risk patients with atypical glandular cells (AGCs) after 4 to 6 years of follow-up, we reviewed repeated Papanicolaou (Pap) test and surgical pathology results for a 3-year period for 337 patients; 62 (18.4%) had only repeated Pap smears; 84 had Pap smear and histologic evaluations. In a range of repeated Pap smears from 1 to 11 (mean, 4.2), 9 patients had persistent AGCs/atypical squamous cells; remaining Pap smears were judged normal. Histologic follow-up revealed a clinically significant lesion in 110 (40.1%) of 274 patients-low-grade squamous intraepithelial lesion (LSIL), 46; high-grade squamous intraepithelial lesion (HSIL), 47; endocervical adenocarcinoma in situ (AIS), 3; endometrial hyperplasia, 4; endocervical or endometrial adenocarcinoma, 10. Among patients with histologic follow-up, 14 lesions (12.7% of patients with clinically significant lesions) were diagnosed after a mean of 37 months (range, 21-59 months): LSIL, 7; HSIL, 4; AIS, 1; endometrial adenocarcinoma, 2. Seven patients had negative cytologic and/or histologic evaluations between the initial cytologic AGC diagnosis and the final histologic diagnosis. Patients with AGCs are at risk of harboring clinically significant uterine lesions and should be followed up for a substantial period despite initial negative findings.

from:  Women With Atypical Glandular Cells: A Long-Term Follow-up Study in a High-Risk Population
David C. Chhieng, MD, MBA; Sandra Gallaspy, CT(ASCP); Hong Yang, CT(ASCP); Janie Roberson, SCT(ASCP); Isam Eltoum, MD, MBA