Ovarian Cancer Community
Nanotechnology proves 100% kill rate/overcomes drug resistance with ova...
About This Community:

This patient support community is for discussions relating to ovarian cancer, biopsy, chemotherapy, clinical trials, genetics, hysterectomy, immunotherapy, radiation therapy, screening, and staging.

Font Size:
A
A
A
Background:
Blank
Blank
Blank
Blank Blank

Nanotechnology proves 100% kill rate/overcomes drug resistance with ovarian cancer

http://www.alanpeto.com/ovarian_cancer/blogs/46/

Double-Duty Nanoparticles Overcome Drug Resistance in Tumors

Cancer cells, like bacteria, can develop resistance to drug therapy. In fact, research suggests strongly that multidrug resistant cancer cells that remain alive after chemotherapy are responsible for the reappearance of tumors and the poor prognosis for patients whose cancer recurs. Indeed, multidrug resistance occurs in over 50% of patients whose ovarian cancer relapses, accounting in large part for the high mortality associated with ovarian cancer.

In an attempt to circumvent the mechanisms that cancer cells use to avoid cell death following chemotherapy, researchers at Northeastern University, led by Mansoor Amiji, Ph.D., have created a polymeric nanoparticle that delivers a one-two punch to multidrug resistant ovarian cancer cells. The first blow comes from the drug ceramide, which overwhelms an enzyme that drug-resistant tumor cells use to avoid apoptosis, the programmed cell death that chemotherapy triggers. The nanoparticle delivers its second blow in the form of paclitaxel, a potent anticancer agent used as a first-line therapy for ovarian cancer. Amiji, the principal investigator of one of the National Cancer Institute's Cancer Nanotechnology Platform Partnerships, and his colleagues published their results in the journal Cancer Research.

Using drug-resistant ovarian cancer cells growing in culture, the investigators showed that treatment with the multifunctional nanoparticle produced 100% mortality among the cultured cells. Moreover, ceramide co-therapy sensitized the drug-resistant cells to such a degree that they became as sensitive to the cell-killing effects of paclitaxel as are non-drug-resistant ovarian tumor cells. The researchers note that followup experiments showed that nanoparticle-delivered ceramide, in fact, did restore the drug-resistant cells' ability to undergo apoptosis.

This work, which was supported by the National Cancer Institute's Alliance for Nanotechnology in Cancer, is detailed in the paper "Modulation of intracellular ceramide using polymeric nanoparticles to overcome multidrug resistance in cancer." Investigators from the Massachusetts General Hospital also participated in this study. An abstract of this paper is available through PubMed.

View abstract: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17510414&query_hl=1&itool=pubmed_docsum

http://nano.cancer.gov/programs/platforms/northwestern_university.asp
Related Discussions
2 Comments
Blank
Avatar_n_tn
Alan,

There's great hope with this method. I am so glad they are working on it with ovarian.

Here's something I read this morning. (about the poisoning that I mentioned with an Atlanta oncologist) Maybe he wasn't far off--chemo is similar.

This is quoted from Ivanhoe email.

Something that fascinates me, for instance, is how arsenic, a known, deadly poison, has successfully helped treat certain leukemia patients. Read our report from Wake Forest on the exciting results of the trial study, where 77-percent of the APL patients who got small amounts of arsenic therapy along with their standard cancer treatment remained alive and in remission three years later, compared to only 59-percent of those solely on standard chemo.



I'm off to Florida for a week to see my daughter.

Helen
Blank
Avatar_m_tn
Helen,

I remember reading about a person who died in the infusion center from REGULAR chemotherapy because they just gave them too much.  Chemo is just so harmful (in general).  I'm sad our 21st century is not the stuff of sci-fi because the day we can get rid of it and go to something better will be a good day!

Take care on your trip!

Alan
Blank
Continue discussion Blank
Blank
Weight Tracker
Weight Tracker
Start Tracking Now
Ovarian Cancer Community Resources
RSS Expert Activity
242532_tn?1269553979
Blank
Emotional Eating Control: How to St...
Aug 28 by Roger Gould, M.D.Blank
233488_tn?1310696703
Blank
New Cannabis Article from NORTH Mag...
Jul 20 by John C Hagan III, MD, FACS, FAAOBlank
242532_tn?1269553979
Blank
3 Reasons Why You are Still Binge E...
Jul 14 by Roger Gould, M.D.Blank
Top Ovarian Cancer Answerers
667078_tn?1316004535
Blank
HVAC
Durham, NC
Avatar_f_tn
Blank
old_before_my_time