Ovarian Cancer detected during December 2008. After 3 cycles of Carboplatin and paclitaxcel, operated upon and cyst removed during January 2009. Completed the remaining 3 cycles of Chemotherapy (Carboplatin and paclitaxcel). CA 125 value started to increased and went up to 1700+. Hence Lipodox was advised by the doctor and four cycles was administered during January 2010. Upto the third cycle the CA 125 was coming down. After the 4th cycle of Lipodox the CA 125 value again went up to 1700+. Again the doctor suggested gemcitabine which was also administered (1 cycle - 3 doses) during May 2010. After that CA value went upto 1902. Now we are continuing with gemcitable 2nd cycle - 2nd dose. Even now the CA 125 has gone up to 2046. Please advise as to whether the treatment is on the right path or else we have to switch over to some other medicine.
Sorry to hear what you are going through. Gemzar (gemcitabine) is a common treatment given to women who are "platinum sensitive" (they responded well to first line platinum based chemo and did not recur within 6 months).
Most patients will, at some time or other start to develop resistance to chemo drugs. This may be what is happening with you and Gemzar. I think it is wise to speak to your doctor and discuss other reasons why you CA125 numbers may be increasing. CA125 is not 100% reliable so eliminating other reasons for an increase would be a good first step.
As you were platinum sensitive, going back to Carbo/Taxol might be a good thing to do - clearly though this is a medical decision and I am not qualified..
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