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Ovarian Cancer (Expert Forum)
POST chemo
Answered by
Annekathryn Goodman, M.D. - Gynecologic Cancers, Complex Gynecologic, Surgeries, Palliative Care, Acupuncture
Massachusetts General Hospital Cancer Center
Boston - MA
Doctor's Answer
by Annekathryn Goodman, M.D., Oct 14, 2007 08:55AM
, Oct 14, 2007 08:55AM
Dear Carey,
Yes! I find the joint/muscle side effects of taxol based chemo to be mysterious. There are two different kinds of experiences that my patients tell me about:
1-severe joint and muscle pain about a week after each treatment
2- the development of an arthritis syndrome after chemotherapy is completed.
I do not know if these 2 situations are related or have a completely different mechanism of action.
I did a little search on this. Interestingly, taxol has been used experimentally to treat rheumatoid arthritis. It seems to inhibit the formation of collagen hat is involved in joint deformities. I did not see too much else int he literature in my quick search. I have wondered whether stopping taxol uncovers a predisposition to arthritis. Or perhaps it is completely unrelated and the joint stiffness is due to the loss of estrogen that comes with surgery.
best wishes
Yes! I find the joint/muscle side effects of taxol based chemo to be mysterious. There are two different kinds of experiences that my patients tell me about:
1-severe joint and muscle pain about a week after each treatment
2- the development of an arthritis syndrome after chemotherapy is completed.
I do not know if these 2 situations are related or have a completely different mechanism of action.
I did a little search on this. Interestingly, taxol has been used experimentally to treat rheumatoid arthritis. It seems to inhibit the formation of collagen hat is involved in joint deformities. I did not see too much else int he literature in my quick search. I have wondered whether stopping taxol uncovers a predisposition to arthritis. Or perhaps it is completely unrelated and the joint stiffness is due to the loss of estrogen that comes with surgery.
best wishes
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