Recurrence with ascites

Dear doctor.  My mom is 65 y/o who wad diagosed with stage III-c ovarian cancer in November of 2006. She had tah/ bso with debulking and omentectomy. She underwent six chemo treatments of taxol/carboplatin and kept normal ca125 for 7 months. Her ca125 rose and had a couple of suspicious areas perisplenic. Therefore, they elected to repeat six more treatments of taxol/carbo and again her ca125 came back to normal with clear cat scan. Then six months later her ca125 began to rise again and she was begun on doxil which wad working great but she developed adverse side effects and had to stop treatment. She was then begun on avastin and she had some reduction in ca125 but not a complete response. Therefore, gemzar and cistplatinvwas added to her regimen. This stablized her ca125 but did not bring to normal range. She had to have break from chemo as it was totally taking her life away. Her ca125 was at 80 and she had a completely clear cat scan. She had eight-week break and then her ca125 shot up to 400 and then 742. She was begun on topotecan and had one treatment and then the ascites developed and caused bowel obstruction. She had to have a paracetesis to remove 1600 cc.  Now they r wanting to start etoposide orally at 50 mg bid.  I have read about ip therapies, infusing warmed chemotherapy into abdominal cavity, etc.  What options do we have and what should our next step be???