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rising ca125 inspite of avastin
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rising ca125 inspite of avastin

my mom is on avastin (1 positive lymphnode on pet scan stable for 2 years) but her ca125 rised gradually from21 to 1000. any explanation?
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Hi There,
the next step is to get a CT scan or PET scan to see if there is any growth of cancer.  If indeed the scan does not show any change, most oncologists would not start a new chemotherapy.

The most likely reason for a rising CA 125 is increase in cancer cells.But if the scan does not show anything yet (there is a size limit in what a scan can see; anything less than half a cm will not be picked up), the cancer is not causing any clinical illness.

The only question is whether the avastin should be stopped.
This is an important question that should be discussed with your mother's oncologist.

occasionally other conditions can cause an elevation in the CA 125 such as infection and inflammation.

I know it is nerve wracking to continue watchful waiting but that would be the standard approach.
best wishes
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