I understand your high tolerance issues and think that a change would be in order. Opana is strong and may be a good choice. It's too bad but it doesn't seem like dr. Jeffery the subdoc comes around here any more and this is called "ask the expert" right? All the best to you.
Don't you know that methadone blocks all of the pain receptors in your brain, not allowing any other opioid to reach the receptor? All you are doing is taking a big risk for an overdose. Talk to your Dr. Choose one or the other. Peace
Methadone is used often now in chronic pain management and in those doses, it does not have any blocking effect of other opiates. In fact, most people on Methdaone are also on a short acting opiate for breakthrough pain.
It is used in addiction recovery in different dosages...but that is usually to block heroine and just reduce cravings for medications but it doesn't have any type of "blocking" ingredient.
There are medications like Suboxone (which contains Buprenorphine and Naloxone) or Subutex (Buprenorphine) to help those with addiction issues.
But again...Suboxone in certain dosages can be used for chronic pain management as well. Buprenorphine is a semi-synthetic opiod. In higher dosages it can act as a partial opiod antagonist.
The only one that actually blocks other opiates is Naloxone itself. It is a pure opiod antagonist.
When someone actually overdoses and winds up in the ER...some can be quickly given Narcan (Naloxone) to help reverse the effects of the opiates taken.
I was on methadone for many years too control my pain. Methadone when using it every day does block other meds from working. The the only medication that works with methadone for break through is morphine. Ask your Dr. to give you morphine instead of oxycodone. This will help with your pain.
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