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I experienced shorter temper on the fentanyl patches, but it tapered off with time. If flare-ups occur during the third day, you might want to ask the doctor to allow changing patches every two days, leaving the old patch on for the third day (for a one day 'overlap'). This can keep the fentanyl level more uniform (if insurance allows it). It might also help if he also wears a clonidine patch (such as the Catapres-TTS series). These can improve pain relief, and also reduce withdrawal symptoms at the end of the fentanyl patch's useful life. Another option may be to use an intrathecal pump (like a morphine pump). Since the pain med is delivered directly to the central nervous system, significantly lower dosages are required. This can really reduce side effects, resulting in a vast improvement in quality of life.