Proglumide? Kratom?

[MrsSinger]

Okay a co worker told me about an herb called Kratom. Many people use it to get through opiate withdrawals. I read a few different posts and forums online about using this for pain management as well. Has anyone heard of this or tried it?  

While researching it I came across a medicine called Proglumide. It used to be used in medicines for stomach ulcers but is no longer used, due to other new upcoming medication that worked much better.

Below is part of a web page I read online. http://www.erowid.org/chemicals/opiates/opiates_info3.shtml

Many people are unaware that both enhanced effectiveness of narcotic analgesics AND prevention or reversal of tolerance is readily achievable through the oral use of up to 200-250 mg of Proglumide [(DL)-4-Benzamido-N,N-dipropylglutaramic acid]. [See Ott 1999; Watkins et al. 1984]


Has anyone heard of this drug? Or even tried it?

I have chronic back pain and it sounds very interesting to me. If you have chronic pain and take pain medication i'm sure you will be interested as well. I have a very high tolerance for my pain medication, as well as other medication that I don't even take regularly. I also read that the Proglumide is proven safe for humans. That makes me feel a tad bit better about trying it.


I'm doing more research before I try either but what do you think? I really want opinions and advice if you understand or have chronic pain.


Thanks :)

And if you don't want to respond on here just message me!!!!  

[Yidori]

I have not heard of Proglumide, and I thought my husband and I had searched all through out the internet with his former doctor for anything that may help him avoid tollaerance and get more out of his medications.

My husband suffers from NDPH (New Daily Persistant Headache) which is a never ending tension like headache, which to date has no treatment that helps, other than narcotic drugs.  My husband has been on his meds for over a year now, but we are always behind because he becomes tollerant to his dosage so quickly.  While we have found studies on some medications that may "reset the clock" on tollerance, I have not heard of this one, and the ones I do know, the doctor just didn't feel comfortable trying with my husband.  

I have heard of Kratom, though in the use of treating people in rehab, not as pain management.  My sister was once a heroin addict.  Five years back she went into rehab to end her addiction once and for all.  She was terrified of methodone and what she had read about it, and while she ended up letting them treat her with it, Kratom was an alternative that said she could try.  They didn't feel it was nearly as effective, but she needed something to get through withdraw.  As a opioid receptor agonist, it can stimulate the body (depending on the dose) to trick it into thinking the opioid is present.  

Whether this would work on pain relief, I just don't know and I wouldn't personally let my husband try it based on things on the internet.  Plenty of sites say it is safe, but to watch out that the taker can be just as addicted to the herb as the drug, but that isn't enough for me to take a risk.  The herb is classified as a controled substance is most countries outside the US, and that alone gives me pause.

I might check these out, but I really don't have high hopes and I do not want my husband to get his hopes up.  It is difficult to come to terms with, but sometimes the long hard road is the only one we have to walk.  If you spend all your times looking for shortcuts, you never gain the strength to just start walking.

[Tuckamore]

It's my understanding that this is not used in PM. Kratom is such a plant and not prescribed by physicians to my knowledge..... until that time I have no interest in adding this or anything that is not a physician's RX to my pain regimen.

I see DOs who are pretty open to holistic treatments and often take the less harmful approache..... This is not one of them. I follow my physician's instructions to a T, unless I disagree and then we have an open and honest discussion about the disagreement.

That's my personal opinion for what it's worth.

~Tuck