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I would think of: snoring (some kind of obstruction in nasal area or sinuses), night terrors, pain, separation anxiety, pinworms, or diabetes.
Good luck...it is difficult on you as a parent to continually lose sleep, but it is hard on the child also. Try to establish regular sleep patterns with calming pre-bedtime routines, limit daytime napping, and every so often, get grandma to keep the kids overnight so you and hubby can sleep.