I adore having my pet rats but I get them when they're young. Never adopted adults before. I have cared for someone's rats while he was on vacation. They were a bit shy the first couple of days but they warmed up to me quite quickly with hand-held treats. I guess it would depend on how much handling they received from their previous owners. Our rats are comfortable being held by anyone that comes to visit. Then again, we let them out about an hour a day to run in the living room and play. We wrestle and play peek-a-boo with them under a small blanket. Yeah, I know this all sounds weird but it's fun for us all. If we just sit still, they get annoyed and crawl up to our face and lick as if to say - hey, move it! Just take your time with the new pets, watch their reactions. The last thing you want is a rat bite. Ouch!
I just noticed that you said the rats were 2 years old. That's getting old and they've probably slowed down quite a bit. That will help.
The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. MedHelp is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. We offer this Site AS IS and without any warranties. By using this Site you agree to the following Terms and Conditions. If you think you may have a medical emergency, call your physician or 911 immediately.